Wound Healing Compounding

Wound healing is a complex process of restoring cellular structures and tissue layers. The human wound healing process can be categorized into 3 specific phases: the inflammatory phase, the proliferative phase, and the remodeling phase. Within these 3 distinct phases, there is a complex and coordinated series of events that includes chemotaxis, phagocytosis, neocollagenesis, collagen degradation, and collagen remodeling. Additionally, angiogenesis, epithelization, and the production of new glycosaminoglycans (GAGs) and proteoglycans are essential to the wound healing process. The combination of these biological processes results in the replacement of normal skin structures with fibroblastic mediated scar tissue.

In addition to traditional prescriptions, there are alternatives, including compounded topical products, which consist of phenytoin, misoprostol, metronidazole, or combinations of the three, and nifedipine. The literature tends to show positive outcomes with the use of these products with little to no side effects.

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